概述

  • 产品名称
    Anti-NKG2D抗体[1D11] (FITC)
    参阅全部 NKG2D 一抗
  • 描述
    小鼠单克隆抗体[1D11] to NKG2D (FITC)
  • 宿主
    Mouse
  • 偶联物
    FITC. Ex: 493nm, Em: 528nm
  • 经测试应用
    适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tissue/ cell preparation: NKL Cells

  • 常规说明
    Spleen cells from immunised RBF/DnJ mice were fused with cells of the p3 mouse myeloma cell line.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 纯化说明
    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
  • 克隆
    单克隆
  • 克隆编号
    1D11
  • 同种型
    IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab35035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt 1/1 - 1/10.

ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

靶标

  • 功能
    Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
  • 组织特异性
    Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells. Expressed in interferon-producing killer dendritic cells (IKDCs).
  • 序列相似性
    Contains 1 C-type lectin domain.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
    • 别名
      • CD314 antibody
      • CD314 antigen antibody
      • D12S2489E antibody
      • Killer cell lectin like receptor subfamily K member 1 antibody
      • Killer cell lectin-like receptor subfamily K member 1 antibody
      • KLR antibody
      • KLRC4 KLRK1 readthrough antibody
      • KLRK1 antibody
      • NK cell receptor D antibody
      • NK lectin-like receptor antibody
      • NKG2 D activating NK receptor antibody
      • NKG2 D type II integral membrane protein antibody
      • NKG2-D antibody
      • NKG2-D type II integral membrane protein antibody
      • NKG2-D-activating NK receptor antibody
      • Nkg2d antibody
      • NKG2D_HUMAN antibody
      • NKLLR antibody
      • NKR P2 antibody
      • Nkrp2 antibody
      see all

    文献

    This product has been referenced in:
    • Vyas M  et al. Soluble NKG2D ligands in the ovarian cancer microenvironment are associated with an adverse clinical outcome and decreased memory effector T cells independent of NKG2D downregulation. Oncoimmunology 6:e1339854 (2017). Flow Cyt ; Human . Read more (PubMed: 28932639) »
    • Reiners KS  et al. Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients. Mol Ther 21:895-903 (2013). Flow Cyt ; Human . Read more (PubMed: 23459515) »

    See all 2 Publications for this product

    发表研究结果有使用 ab35035？请让我们知道，以便我们可以引用本数据表中的参考文章。

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