Anti-NKD2抗体(ab67911)

概述

  • 产品名称Anti-NKD2抗体
    参阅全部 NKD2 一抗
  • 描述
    小鼠多克隆抗体to NKD2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    NKD2 full length human protein

  • 阳性对照
    • NKD2 transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab67911 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 37 kDa (predicted molecular weight: 50 kDa).

靶标

  • 功能Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.
  • 组织特异性Expressed in kidney, lung, pancreas and spleen.
  • 序列相似性Belongs to the NKD family.
    Contains 1 EF-hand domain.
  • 发展阶段Expressed in fetal kidney and lung.
  • 结构域The N-terminal domain comprising the first 217 amino acid residues is mostly unstructured.
  • 翻译后修饰Ubiquitinated, leading to rapid proteasomal degradation. Interaction with TGFA interferes with RNF25 binding and protects against ubiquitination mediated by RNF25.
  • 细胞定位Cell membrane. Cytoplasm. Cytoplasmic vesicle.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hNkd2 antibody
    • Naked 2 antibody
    • Naked-2 antibody
    • nkd2 antibody
    • NKD2_HUMAN antibody
    • Protein naked cuticle homolog 2 antibody
    see all

Anti-NKD2 antibody 图像

  • All lanes : Anti-NKD2 antibody (ab67911) at 1/500 dilution

    Lane 1 : NKD2 transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

    Predicted band size : 50 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)

Anti-NKD2 antibody (ab67911)参考文献

ab67911 has not yet been referenced specifically in any publications.

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