概述

  • 产品名称Anti-NIR1抗体
    参阅全部 NIR1 一抗
  • 描述
    山羊多克隆抗体to NIR1
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide:

    SWARGPPKFESVP

    , corresponding to C terminal amino acids 962-974 of Human NIR1 (UniProt ID: Q9BZ71).

  • 阳性对照
    • Human brain cortex

性能

应用

Our Abpromise guarantee covers the use of ab115593 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/16000.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.
  • 组织特异性Detected in brain and spleen, and at low levels in ovary.
  • 疾病相关Defects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) [MIM:600977]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
  • 序列相似性Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
    Contains 1 DDHD domain.
  • 细胞定位Endomembrane system.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CORD5 antibody
    • Membrane associated phosphatidylinositol transfer protein 3 antibody
    • membrane-associated 3 antibody
    • Membrane-associated phosphatidylinositol transfer protein 3 antibody
    • MGC157740 antibody
    • MGC157741 antibody
    • NIR 1 antibody
    • NIR-1 antibody
    • NIR1 antibody
    • Phosphatidylinositol transfer protein antibody
    • Phosphatidylinositol transfer protein, membrane-associated 3 antibody
    • PITM3_HUMAN antibody
    • PITPnm 3 antibody
    • PITPNM antibody
    • PITPNM family member 3 antibody
    • Pitpnm3 antibody
    • PYK2 N terminal domain interacting receptor 1 antibody
    • Pyk2 N-terminal domain-interacting receptor 1 antibody
    • RDGBA3 antibody
    • Retinal degeneration B alpha 3 antibody
    see all

Anti-NIR1 antibody 图像

  • ab115593, at 5 µg/ml, staining NIR1 in formalin fixed, paraffin embedded Human brain, cortex by Immunohistochemistry. After incubation with the primary antibody, slides were incubated with biotinylated anti-goat secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-NIR1 antibody (ab115593)参考文献

ab115593 has not yet been referenced specifically in any publications.

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