概述

  • 产品名称
  • 描述
    兔多克隆抗体to NIPAL4
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 16-45 of Human NIPAL4 (NP_001092757.1, NP_001165763.1).

  • 阳性对照
    • Mouse liver tissue lysates.

性能

应用

Our Abpromise guarantee covers the use of ab107979 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

靶标

  • 功能
    Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway.
  • 组织特异性
    Highly expressed in brain, lung, stomach, keratinocytes and leukocytes, and in all other tissues tested except liver, thyroid and fetal brain.
  • 疾病相关
    Defects in NIPAL4 are the cause of ichthyosis congenital autosomal recessive ichthyin-related (ARCII) [MIM:612281]. ARCII is a disorder of keratinization with abnormal differentiation and desquamation of the epidermis. The phenotype usually presents as non-bullous congenital ichthyosiform erythroderma (NCIE) with fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Some of the families may show a more lamellar phenotype (lamellar ichthyosis).
  • 序列相似性
    Belongs to the NIPA family.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 9530066K23Rik antibody
    • ICHN antibody
    • Ichthyin antibody
    • ICHYN antibody
    • Magnesium transporter NIPA4 antibody
    • NIPA like 4 antibody
    • NIPA like domain containing 4 antibody
    • NIPA-like protein 4 antibody
    • NIPA4_HUMAN antibody
    • NIPAL4 antibody
    • Non-imprinted in Prader-Willi/Angelman syndrome region protein 4 antibody
    • RGD1309452 antibody
    • RP23-29H5.5 antibody
    see all

图片

  • Anti-NIPAL4 antibody (ab107979) at 1/100 dilution + Mouse liver tissue lysates at 15 µg

    Predicted band size : 50 kDa

实验方案

文献

ab107979 has not yet been referenced specifically in any publications.

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