概述

  • 产品名称
    Anti-Niemann Pick C2抗体
    参阅全部 Niemann Pick C2 一抗
  • 描述
    山羊多克隆抗体to Niemann Pick C2
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat
  • 免疫原

    Synthetic peptide:

    QAEPLHFKDCGSK

    , corresponding to internal sequence amino acids 18-30 of Mouse Niemann Pick C2 (NP_075898).

  • 阳性对照
    • Mouse kidney lysate

性能

应用

Our Abpromise guarantee covers the use of ab114047 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 16 kDa (predicted molecular weight: 16 kDa).

靶标

  • 功能
    May be involved in the regulation of the lipid composition of sperm membranes during the maturation in the epididymis.
  • 组织特异性
    Epididymis.
  • 疾病相关
    Defects in NPC2 are the cause of Niemann-Pick disease type C2 (NPDC2) [MIM:607625]. A lysosomal storage disorder that affects the viscera and the central nervous system. It is due to defective intracellular processing and transport of low-density lipoprotein derived cholesterol. It causes accumulation of cholesterol in lysosomes, with delayed induction of cholesterol homeostatic reactions. Niemann-Pick disease type C2 has a highly variable clinical phenotype. Clinical features include variable hepatosplenomegaly and severe progressive neurological dysfunction such as ataxia, dystonia and dementia. The age of onset can vary from infancy to late adulthood.
  • 序列相似性
    Belongs to the NPC2 family.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EDDM1 antibody
    • Epididymal protein 1 antibody
    • Epididymal secretory protein antibody
    • Epididymal secretory protein E1 antibody
    • hE1 antibody
    • Human epididymis-specific protein 1 antibody
    • Niemann-Pick disease type C2 antibody
    • Niemann-Pick disease type C2 protein antibody
    • NPC intracellular cholesterol transporter 2 antibody
    • NPC2 antibody
    • NPC2_HUMAN antibody
    • Tissue specific secretory protein antibody
    see all

图片

  • Anti-Niemann Pick C2 antibody (ab114047) at 0.1 µg/ml + Mouse kidney lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 16 kDa


    Exposure time : 1 hour

实验方案

文献

This product has been referenced in:
  • Twu YC  et al. Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation. Int J Mol Sci 17:N/A (2016). WB . Read more (PubMed: 27420058) »

See 1 Publication for this product

客户评价及客户问答

There are currently no Customer reviews or Questions for ab114047.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册