This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

概述

性能

应用

Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 147 kDa. This antibody did not give bands in initial tests on lysate/cell line, we would welcome your feedback if you have tested this antibody in more suitable positive controls.

靶标

  • 功能
    Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism.
  • 组织特异性
    Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.
  • 序列相似性
    Belongs to the patched family.
    Contains 1 SSD (sterol-sensing) domain.
  • 翻译后修饰
    Highly glycosylated.
  • 细胞定位
    Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Niemann Pick C1 like protein 1 antibody
    • Niemann Pick disease type C1 gene like 1 antibody
    • Niemann-Pick C1-like protein 1 antibody
    • NPC1 LIKE 1 antibody
    • NPC1 Niemann Pick disease type C1 gene like 1 antibody
    • NPC1L1 antibody
    • NPC1L1 splice variant antibody
    • NPCL1_HUMAN antibody
    • Truncated Niemann Pick C1 like protein 1 antibody
    see all

实验方案

Anti-Niemann Pick C1 Like 1 antibody (ab121000)参考文献

This product has been referenced in:
  • Zhong CY  et al. Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice. Sci Rep 5:10512 (2015). WB ; Mouse . Read more (PubMed: 26015368) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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