Anti-Nicotinic Acetylcholine Receptor gamma抗体[C9] (ab11151)


  • 产品名称Anti-Nicotinic Acetylcholine Receptor gamma抗体[C9]
    参阅全部 Nicotinic Acetylcholine Receptor gamma 一抗
  • 描述
    小鼠单克隆抗体[C9] to Nicotinic Acetylcholine Receptor gamma
  • 特异性ab11151 binds to Human AChR - gamma subunit found only in foetal AChR. Exhibits homogenous, high avidity binding to the receptor. Binds human recombinant gamma subunit on Western blots.
  • 经测试应用适用于: IHC-Fr, IP, WB, Flow Cytmore details
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat, Chicken
  • 免疫原

    Full length protein (Human).



Our Abpromise guarantee covers the use of ab11151 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/3.
IP 1/100.
WB 1/100. Predicted molecular weight: 62.4 kDa.
Flow Cyt 1/1. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.


  • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 疾病相关Defects in CHRNG are a cause of multiple pterygium syndrome lethal type (MUPSL) [MIM:253290]. Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent.
    Defects in CHRNG are a cause of multiple pterygium syndrome Escobar variant (MUPSE) [MIM:265000]; also known as nonlethal type multiple pterygium syndrome. Escobar syndrome is a non-lethal form of arthrogryposis multiplex congenita. It is an autosomal recessive condition characterized by excessive webbing (pterygia), congenital contractures (arthrogryposis), and scoliosis. Variable other features include intrauterine death, congenital respiratory distress, short stature, faciocranial dysmorphism, ptosis, low-set ears, arachnodactyly and cryptorchism in males. Congenital contractures are common and may be caused by reduced fetal movements at sensitive times of development. Possible causes of decreased fetal mobility include space constraints such as oligohydramnion, drugs, metabolic conditions or neuromuscular disorders including myasthenia gravis. is a.
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub-subfamily.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acetylcholine receptor muscle gamma subunit antibody
    • Acetylcholine receptor protein gamma chain precursor antibody
    • Acetylcholine receptor subunit gamma antibody
    • ACHG antibody
    • ACHG_HUMAN antibody
    • Achr 3 antibody
    • AChR antibody
    • Achr3 antibody
    • ACHRG antibody
    • ACRG antibody
    • Cholinergic receptor nicotinic gamma antibody
    • Cholinergic receptor nicotinic gamma polypeptide antibody
    • CHRNG antibody
    • MGC133376 antibody
    see all

Anti-Nicotinic Acetylcholine Receptor gamma antibody [C9] (ab11151)参考文献

ab11151 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 25 µg
Gel Running Conditions Non-reduced Denaturing (10% gel BioRad, Running Buffer BioRad)
Sample Mouse Tissue lysate - whole (tibialis muscle)
Specification tibialis muscle
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 26°C

Ms. Lisa Marienhoff

Verified customer

提交于 Nov 05 2013