Anti-Nicotinic Acetylcholine Receptor epsilon抗体(ab65180)

概述

  • 产品名称Anti-Nicotinic Acetylcholine Receptor epsilon抗体
    参阅全部 Nicotinic Acetylcholine Receptor epsilon 一抗
  • 描述
    兔多克隆抗体to Nicotinic Acetylcholine Receptor epsilon
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, a wide range of other species
  • 免疫原

    Synthetic peptide derived from C terminal human Nicotinic Acetylcholine Receptor epsilon.

性能

应用

Our Abpromise guarantee covers the use of ab65180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 55 kDa.

靶标

  • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 疾病相关The muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
    Myasthenic syndrome, congenital, 4A, slow-channel
    Myasthenic syndrome, congenital, 4B, fast-channel
    Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
  • 细胞定位Cell junction, synapse, postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acetylcholine receptor subunit epsilon antibody
    • ACHE_HUMAN antibody
    • AChR antibody
    • AchR epsilon subunit antibody
    • ACHRE antibody
    • Cholinergic receptor, nicotinic, epsilon polypeptide antibody
    • Chrne antibody
    • CMS1D antibody
    • CMS1E antibody
    • CMS2A antibody
    • FCCMS antibody
    • SCCMS antibody
    see all

Anti-Nicotinic Acetylcholine Receptor epsilon antibody (ab65180)参考文献

ab65180 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 25 µg
Gel Running Conditions Non-reduced Denaturing (10% gel BioRad, Running Buffer BioRad.)
Sample Mouse Tissue lysate - whole (tibialis muscle)
Specification tibialis muscle
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 26°C
Username

Ms. Lisa Marienhoff

Verified customer

提交于 Dec 03 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"