Anti-Nicotinic Acetylcholine Receptor epsilon抗体(ab65180)
- 数据表
- 具体的参考文献 (1)
- 实验方案
概述
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产品名称Anti-Nicotinic Acetylcholine Receptor epsilon抗体
参阅全部 Nicotinic Acetylcholine Receptor epsilon 一抗 -
描述兔多克隆抗体to Nicotinic Acetylcholine Receptor epsilon
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宿主Rabbit
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经测试应用适用于: IHC-P, WBmore details
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种属反应性与反应: Mouse, Human
预测可用于: Rat, a wide range of other species
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免疫原
Synthetic peptide derived from C terminal human Nicotinic Acetylcholine Receptor epsilon.
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
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存储溶液Preservative: None
Constituents: Whole serum -
纯度Whole antiserum
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab65180 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | Use at an assay dependent concentration. | |
| WB | 1/500 - 1/5000. Predicted molecular weight: 55 kDa. |
靶标
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功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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疾病相关The muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
Myasthenic syndrome, congenital, 4A, slow-channel
Myasthenic syndrome, congenital, 4B, fast-channel
Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency -
序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
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细胞定位Cell junction, synapse, postsynaptic cell membrane. Cell membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 1145 Human
- Entrez Gene: 11448 Mouse
- Entrez Gene: 29422 Rat
- GenBank: NP_033733.1 Mouse
- Omim: 100725 Human
- SwissProt: Q04844 Human
- SwissProt: P20782 Mouse
- SwissProt: P09660 Rat
see all -
别名
- Acetylcholine receptor subunit epsilon antibody
- ACHE_HUMAN antibody
- AChR antibody
see all
文献
This product has been referenced in:
- Saeed S et al. Conformational co-dependence between Plasmodium berghei LCCL proteins promotes complex formation and stability. Mol Biochem Parasitol 185:170-3 (2012). Read more (PubMed: 22877575) »
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"