Anti-Nicotinic Acetylcholine Receptor epsilon抗体(ab54624)

概述

  • 产品名称Anti-Nicotinic Acetylcholine Receptor epsilon抗体
    参阅全部 Nicotinic Acetylcholine Receptor epsilon 一抗
  • 描述
    小鼠单克隆抗体to Nicotinic Acetylcholine Receptor epsilon
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 21-131 of Human Nicotinic Acetylcholine Receptor epsilon

性能

应用

Our Abpromise guarantee covers the use of ab54624 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    • 疾病相关The muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
      Myasthenic syndrome, congenital, 4A, slow-channel
      Myasthenic syndrome, congenital, 4B, fast-channel
      Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency
    • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
    • 细胞定位Cell junction, synapse, postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Acetylcholine receptor subunit epsilon antibody
      • ACHE_HUMAN antibody
      • AChR antibody
      • AchR epsilon subunit antibody
      • ACHRE antibody
      • Cholinergic receptor, nicotinic, epsilon polypeptide antibody
      • Chrne antibody
      • CMS1D antibody
      • CMS1E antibody
      • CMS2A antibody
      • FCCMS antibody
      • SCCMS antibody
      see all

    Anti-Nicotinic Acetylcholine Receptor epsilon antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab54624 Nicotinic Acetylcholine Receptor epsilon antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Anti-Nicotinic Acetylcholine Receptor epsilon antibody (ab54624)参考文献

    ab54624 has not yet been referenced specifically in any publications.

    Product Wall

    Application Western blot
    Sample Human Cell lysate - nuclear (hek cell transfected with AChR and human muscle)
    Gel Running Conditions Reduced Denaturing (1%)
    Loading amount 20 µg
    Specification hek cell transfected with AChR and human muscle
    Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 24°C
    Username

    Pedro Cruz

    Verified customer

    提交于 Jun 08 2015

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"