Anti-Nicotinic Acetylcholine Receptor epsilon抗体(ab49141)

概述

  • 产品名称Anti-Nicotinic Acetylcholine Receptor epsilon抗体
    参阅全部 Nicotinic Acetylcholine Receptor epsilon 一抗
  • 描述
    兔多克隆抗体to Nicotinic Acetylcholine Receptor epsilon
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    A region within synthetic peptide: PGSRPVREPE DTVTISLKVT LTNLISLNEK EETLTTSVWI GIDWQDYRLN, corresponding to N terminal amino acids 37-86 of Human Nicotinic Acetylcholine Receptor epsilon

  • 阳性对照
    • HepG2 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab49141 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/375,000.

WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 疾病相关The muscle AChR is the major target antigen in the autoimmune disease myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
    Myasthenic syndrome, congenital, 4A, slow-channel
    Myasthenic syndrome, congenital, 4B, fast-channel
    Myasthenic syndrome, congenital, 4C, associated with acetylcholine receptor deficiency
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Epsilon/CHRNE sub-subfamily.
  • 细胞定位Cell junction, synapse, postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acetylcholine receptor subunit epsilon antibody
    • ACHE_HUMAN antibody
    • AChR antibody
    • AchR epsilon subunit antibody
    • ACHRE antibody
    • Cholinergic receptor, nicotinic, epsilon polypeptide antibody
    • Chrne antibody
    • CMS1D antibody
    • CMS1E antibody
    • CMS2A antibody
    • FCCMS antibody
    • SCCMS antibody
    see all

Anti-Nicotinic Acetylcholine Receptor epsilon antibody 图像

  • Anti-Nicotinic Acetylcholine Receptor epsilon antibody (ab49141) at 1.25 µg/ml + HepG2 Cell Lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50,000

    Predicted band size : 55 kDa
    Observed band size : 55 kDa

Anti-Nicotinic Acetylcholine Receptor epsilon antibody (ab49141)参考文献

This product has been referenced in:
  • Mastrangelo L  et al. Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells. Cancer Res 68:5487-91 (2008). WB ; Human . Read more (PubMed: 18593952) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab49141.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"