Anti-Nicotinic Acetylcholine Receptor beta抗体[B3] (ab11150)


  • 产品名称Anti-Nicotinic Acetylcholine Receptor beta抗体[B3]
    参阅全部 Nicotinic Acetylcholine Receptor beta 一抗
  • 描述
    小鼠单克隆抗体[B3] to Nicotinic Acetylcholine Receptor beta
  • 特异性Ab11150 binds human AChR Beta subunit. Exhibits homogenous, high avidity binding to the receptor. Binding to recombinant beta subunit demonstrated on Western blotting.
  • 经测试应用适用于: Flow Cyt, IHC-Fr, WB, IPmore details
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat, Chicken
  • 免疫原

    Full length protein (Human).


  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号B3
  • 骨髓瘤NS1
  • 同种型IgG1
  • 研究领域


Our Abpromise guarantee covers the use of ab11150 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt 1/1. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
IHC-Fr 1/3.
WB 1/100. Predicted molecular weight: 60.1 kDa.
IP 1/100.


  • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 疾病相关Defects in CHRNB1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS) [MIM:601462]. SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes.
    Defects in CHRNB1 are a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (ACHRDCMS) [MIM:608931]. ACHRDCMS is a post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance.
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acetylcholine receptor protein beta chain precursor antibody
    • Acetylcholine receptor subunit beta antibody
    • ACHB_HUMAN antibody
    • AChR antibody
    • ACHRB antibody
    • Cholinergic receptor nicotinic beta polypeptide 1 (muscle) antibody
    • Chrnb 1 antibody
    • CHRNB antibody
    • chrnb1 antibody
    • CMS1D antibody
    • CMS2A antibody
    • Nicotinic acetylcholine receptor beta subunit precursor antibody
    • SCCMS antibody
    see all

Anti-Nicotinic Acetylcholine Receptor beta antibody [B3] (ab11150)参考文献

ab11150 has not yet been referenced specifically in any publications.

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