Anti-Nicotinic Acetylcholine Receptor beta抗体(ab81982)

概述

  • 产品名称Anti-Nicotinic Acetylcholine Receptor beta抗体
    参阅全部 Nicotinic Acetylcholine Receptor beta 一抗
  • 描述
    山羊多克隆抗体to Nicotinic Acetylcholine Receptor beta
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide:

    C-QEQEDHDALKED

    , corresponding to internal sequence amino acids 448-459 of Human Nicotinic Acetylcholine Receptor beta (NP_000738.2).

  • 阳性对照
    • Human brain (cerebellum, hippocampus, frontal cortex) lysates.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab81982 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab81982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Antibody detection limit dilution 1/1000.
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 57 kDa (predicted molecular weight: 57 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    • 疾病相关Defects in CHRNB1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS) [MIM:601462]. SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes.
      Defects in CHRNB1 are a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (ACHRDCMS) [MIM:608931]. ACHRDCMS is a post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance.
    • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-1/CHRNB1 sub-subfamily.
    • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Acetylcholine receptor protein beta chain precursor antibody
      • Acetylcholine receptor subunit beta antibody
      • ACHB_HUMAN antibody
      • AChR antibody
      • ACHRB antibody
      • Cholinergic receptor nicotinic beta polypeptide 1 (muscle) antibody
      • Chrnb 1 antibody
      • CHRNB antibody
      • chrnb1 antibody
      • CMS1D antibody
      • CMS2A antibody
      • Nicotinic acetylcholine receptor beta subunit precursor antibody
      • SCCMS antibody
      see all

    Anti-Nicotinic Acetylcholine Receptor beta antibody 图像

    • Anti-Nicotinic Acetylcholine Receptor beta antibody (ab81982) at 1 µg/ml + human cerebellum lysate in RIPA buffer at 35 µg

      Predicted band size : 57 kDa
      Observed band size : 57 kDa

    Anti-Nicotinic Acetylcholine Receptor beta antibody (ab81982)参考文献

    ab81982 has not yet been referenced specifically in any publications.

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