Anti-Nicotinic Acetylcholine Receptor beta 2抗体(ab85693)

概述

  • 产品名称Anti-Nicotinic Acetylcholine Receptor beta 2抗体
    参阅全部 Nicotinic Acetylcholine Receptor beta 2 一抗
  • 描述
    山羊多克隆抗体to Nicotinic Acetylcholine Receptor beta 2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rhesus monkey
  • 免疫原

    Synthetic peptide:

    QPRHHCARQRLR

    , corresponding to internal sequence amino acids 351-362 of Human Nicotinic Acetylcholine Receptor beta 2 (NP_000739.1).

  • 阳性对照
    • Human Brain (Cerebellum, Cerebral Cortex) lysates.

性能

应用

Our Abpromise guarantee covers the use of ab85693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 57 kDa).

靶标

  • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 疾病相关Defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3) [MIM:605375]. ENFL3 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acetylcholine receptor beta 2 neural antibody
    • ACHB2_HUMAN antibody
    • ACHN antibody
    • AChR antibody
    • Acrb 2 antibody
    • Acrb2 antibody
    • b2 nAchR antibody
    • Cholinergic receptor nicotinic beta 2 antibody
    • Cholinergic receptor nicotinic beta polypeptide 2 antibody
    • Cholinergic receptor nicotinic beta polypeptide 2 neuronal antibody
    • cholinergic receptor, nicotinic, beta 2 (neuronal) antibody
    • Chrnb2 antibody
    • EFNL 3 antibody
    • EFNL3 antibody
    • nAChRB2 antibody
    • Neuronal acetylcholine receptor protein beta 2 chain precursor antibody
    • Neuronal acetylcholine receptor protein subunit beta 2 antibody
    • Neuronal acetylcholine receptor subunit beta-2 antibody
    • Neuronal nicotinic acetylcholine receptor beta 2 antibody
    see all

Anti-Nicotinic Acetylcholine Receptor beta 2 antibody 图像

  • Anti-Nicotinic Acetylcholine Receptor beta 2 antibody (ab85693) at 1 µg/ml + Human cerebellum lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 57 kDa
    Observed band size : 48 kDa (why is the actual band size different from the predicted?)

Anti-Nicotinic Acetylcholine Receptor beta 2 antibody (ab85693)参考文献

ab85693 has not yet been referenced specifically in any publications.

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