Anti-Nicotinic Acetylcholine Receptor alpha 5抗体(ab41173)

概述

  • 产品名称Anti-Nicotinic Acetylcholine Receptor alpha 5抗体
    参阅全部 Nicotinic Acetylcholine Receptor alpha 5 一抗
  • 描述
    兔多克隆抗体to Nicotinic Acetylcholine Receptor alpha 5
  • 特异性Antiserum Specificity Polypeptide % Cross Reactivity Nicotinic a5 receptor (460-468) 100%, Nicotinic a5 receptor ~95%, Nicotinic a3 receptor 0%, Nicotinic a4 receptor 0%, Nicotinic a7 receptor 0%, Nicotinic ß2 receptor 0%, Nicotinic ß3 receptor 0%, Nicotinic ß4 receptor 0%.
  • 经测试应用适用于: ICC/IF, ELISA, WBmore details
  • 种属反应性
    与反应: Human, Chimpanzee, Monkey
  • 免疫原

    Synthetic peptide:

    PVHIGNANK

    , corresponding to C terminal amino acids 460-468 of Nicotinic Acetylcholine Receptor alpha 5

性能

应用

Our Abpromise guarantee covers the use of ab41173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF
ELISA
WB
  • 应用说明ELISA: Use at an assay dependent dilution.
    ICC/IF: 1/400.
    WB: 1/1600. Predicted molecular weight: 53 kDa.

    With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
    • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Acetylcholine receptor nicotinic alpha 5 (neuronal) antibody
      • ACHA5_HUMAN antibody
      • AChR antibody
      • Cholinergic receptor neuronal nicotinic alpha polypeptide 5 antibody
      • Cholinergic receptor nicotinic alpha 5 antibody
      • Cholinergic receptor nicotinic alpha polypeptide 5 antibody
      • CHRNA 5 antibody
      • CHRNA5 antibody
      • LNCR2 antibody
      • NACHRA 5 antibody
      • NACHRA5 antibody
      • Neuronal acetylcholine receptor subunit alpha 5 antibody
      • Neuronal acetylcholine receptor subunit alpha-5 antibody
      • Neuronal nicotinic acetylcholine receptor alpha 5 subunit antibody
      • Neuronal nicotinic acetylcholine receptor, alpha5 subunit antibody
      • OTTHUMP00000185019 antibody
      see all

    Anti-Nicotinic Acetylcholine Receptor alpha 5 antibody (ab41173)参考文献

    This product has been referenced in:
    • Calleja-Macias IE  et al. Cholinergic signaling through nicotinic acetylcholine receptors stimulates the proliferation of cervical cancer cells: an explanation for the molecular role of tobacco smoking in cervical carcinogenesis? Int J Cancer 124:1090-6 (2009). WB ; Human . Read more (PubMed: 19048619) »

    See 1 Publication for this product

    Product Wall

    Thank you for your message and for providing this further information. I appreciate the time your customer has spent on these experiments and would be pleased to arrange a replacement or a credit note in compensation. I look forward to hearing from...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"