Anti-Nicotinic Acetylcholine Receptor alpha 4抗体[EPR4563(2)] (ab124832)


  • 产品名称Anti-Nicotinic Acetylcholine Receptor alpha 4抗体[EPR4563(2)]
    参阅全部 Nicotinic Acetylcholine Receptor alpha 4 一抗
  • 描述
    兔单克隆抗体[EPR4563(2)] to Nicotinic Acetylcholine Receptor alpha 4
  • 经测试应用适用于: ICC/IF, WB, IPmore details
    不适用于: Flow Cyt,ICC or IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human Nicotinic Acetylcholine Receptor alpha 4.

  • 阳性对照
    • SH-SY5Y, A673, C6 and Neuro-2a cell lysates.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab124832 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration. PubMed: 22483693
WB 1/10000 - 1/50000. Detects a band of approximately 70 kDa (predicted molecular weight: 70 kDa).
IP 1/10 - 1/100.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IHC-P.
  • 靶标

    • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    • 疾病相关Defects in CHRNA4 are the cause of nocturnal frontal lobe epilepsy type 1 (ENFL1) [MIM:600513]; also symbolized ADNFLE. ENFL1 is an autosomal dominant epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
    • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily.
    • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A4 nicotinic receptor antibody
      • Acetylcholine receptor alpha 4 neural antibody
      • Acetylcholine receptor neuronal nicotinic alpha 4 subunit antibody
      • ACH 4 antibody
      • ACH4 antibody
      • ACHA4_HUMAN antibody
      • AChR antibody
      • Acra 4 antibody
      • Acra4 antibody
      • Alpha4 nAChR antibody
      • BFNC antibody
      • Cholinergic receptor nicotinic alpha 4 antibody
      • Cholinergic receptor nicotinic alpha polypeptide 4 antibody
      • CHRNA 4 antibody
      • CHRNA4 antibody
      • EBN 1 antibody
      • EBN antibody
      • EBN1 antibody
      • NACHR antibody
      • NACRA 4 antibody
      • NACRA4 antibody
      • Neuronal acetylcholine receptor subunit alpha-4 antibody
      • Neuronal nicotinic acetylcholine receptor alpha 4 subunit antibody
      see all

    Anti-Nicotinic Acetylcholine Receptor alpha 4 antibody [EPR4563(2)] 图像

    • All lanes : Anti-Nicotinic Acetylcholine Receptor alpha 4 antibody [EPR4563(2)] (ab124832) at 1/10000 dilution

      Lane 1 : SH-SY5Y cell lysate
      Lane 2 : A673 cell lysate
      Lane 3 : C6 cell lysate
      Lane 4 : Neuro-2a cell lysate

      Lysates/proteins at 10 µg per lane.

      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 70 kDa
      Observed band size : 70 kDa

    Anti-Nicotinic Acetylcholine Receptor alpha 4 antibody [EPR4563(2)] (ab124832)参考文献

    ab124832 has not yet been referenced specifically in any publications.

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