Anti-Nicotinic Acetylcholine Receptor alpha 1抗体(ab28489)


  • 产品名称Anti-Nicotinic Acetylcholine Receptor alpha 1抗体
    参阅全部 Nicotinic Acetylcholine Receptor alpha 1 一抗
  • 描述
    兔多克隆抗体to Nicotinic Acetylcholine Receptor alpha 1
  • 特异性ab28489 recognises Nicotinic Acetylcholine Receptor alpha one isoform a and b (muscle isoforms).
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chicken, Cow, Dog
  • 免疫原

    Synthetic peptide derived from residues 349 - 398 of human Nicotinic Acetylcholine Receptor alpha.


  • 阳性对照
    • Human intestine, fetal heart lysate.



Our Abpromise guarantee covers the use of ab28489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.12 µg/ml. Predicted molecular weight: 54 kDa.Can be blocked with Nicotinic Acetylcholine Receptor alpha 1 peptide (ab189888). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use at an assay dependent concentration.
ELISA 1/62500.


  • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 组织特异性Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
  • 疾病相关Defects in CHRNA1 are a cause of multiple pterygium syndrome lethal type (MUPSL) [MIM:253290]. Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent.
    Note=The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
    Defects in CHRNA1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS) [MIM:601462]. SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes.
    Defects in CHRNA1 are a cause of congenital myasthenic syndrome fast-channel type (FCCMS) [MIM:608930]. FCCMS is a congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. In most cases, FCCMS is due to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential.
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acetylcholine receptor subunit alpha antibody
    • ACHA_HUMAN antibody
    • AChR antibody
    • ACHRA antibody
    • CHNRA antibody
    • Cholinergic receptor nicotinic alpha polypeptide 1 antibody
    • Cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) antibody
    • Chrna1 antibody
    • Nicotinic cholinergic receptor alpha 1 antibody
    • Schizophrenia neurophysiologic defect candidate antibody
    see all

Anti-Nicotinic Acetylcholine Receptor alpha 1 antibody 图像

  • Immunohistochemical analysis of Nicotinic Acetylcholine Receptor alpha expression in paraffin embedded human intestine tissue section using 4 µg/ml ab28489. Arrows indicate positively labelled epithelial cells of intestinal villus.
  • Anti-Nicotinic Acetylcholine Receptor alpha 1 antibody (ab28489) at 0.12 µg/ml + Fetal heart lysate

    HRP conjugated anti-Rabbit IgG HRP conjugated anti-Rabbit IgG (diluted in 1: 50,000 - 100,000)

    Predicted band size : 54 kDa

Anti-Nicotinic Acetylcholine Receptor alpha 1 antibody (ab28489)参考文献

ab28489 has not yet been referenced specifically in any publications.

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