Anti-Nicotinic Acetylcholine Receptor alpha 1抗体[61] (ab24631)


  • 产品名称Anti-Nicotinic Acetylcholine Receptor alpha 1抗体[61]
    参阅全部 Nicotinic Acetylcholine Receptor alpha 1 一抗
  • 描述
    大鼠单克隆抗体[61] to Nicotinic Acetylcholine Receptor alpha 1
  • 特异性ab24631 reacts with Neuronal Nicotinic Acetylcholine Receptor a1-Subunits.
  • 经测试应用适用于: ICC/IF, IPmore details
  • 种属反应性
    与反应: Mouse, Human, Torpedo
  • 免疫原

    Denatured Electophorus electricus acetylcholine receptors (AChRs).

  • 表位This antibody binds to the cytoplasmic surface of native and denatured muscle AChR a1 subunits, within amino acids 371-386.
  • 常规说明

    ab24631 is useful in studying AChR synthesis and assembly.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: Ascites
  • Concentration information loading...
  • 纯度Ascites
  • Primary antibody说明ab24631 is useful in studying AChR synthesis and assembly.
  • 克隆单克隆
  • 克隆编号61
  • 同种型IgG2a
  • 研究领域


Our Abpromise guarantee covers the use of ab24631 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent dilution.
IP 1/100.


  • 功能After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 组织特异性Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
  • 疾病相关Defects in CHRNA1 are a cause of multiple pterygium syndrome lethal type (MUPSL) [MIM:253290]. Multiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent.
    Note=The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.
    Defects in CHRNA1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS) [MIM:601462]. SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. SCCMS is caused by kinetic abnormalities of the AChR, resulting in prolonged endplate currents and prolonged AChR channel opening episodes.
    Defects in CHRNA1 are a cause of congenital myasthenic syndrome fast-channel type (FCCMS) [MIM:608930]. FCCMS is a congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. In most cases, FCCMS is due to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential.
  • 序列相似性Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-1/CHRNA1 sub-subfamily.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Acetylcholine receptor subunit alpha antibody
    • ACHA_HUMAN antibody
    • AChR antibody
    • ACHRA antibody
    • CHNRA antibody
    • Cholinergic receptor nicotinic alpha polypeptide 1 antibody
    • Cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) antibody
    • Chrna1 antibody
    • Nicotinic cholinergic receptor alpha 1 antibody
    • Schizophrenia neurophysiologic defect candidate antibody
    see all

Anti-Nicotinic Acetylcholine Receptor alpha 1 antibody [61] (ab24631)参考文献

This product has been referenced in:
  • Tzartos SJ  et al. Mapping of surface structures of electrophorus acetylcholine receptor using monoclonal antibodies. J Biol Chem 256:8635-45 (1981). Read more (PubMed: 6167581) »

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