Antihelminthic， anticancer and protonophric agent. STAT3 inhibitor.
生物学描述Antihelminthic, anticancer and protonophric agent. STAT3 inhibitor (IC50 = 0.25 μM). Shown to inhibit a number of downstream signaling pathways including mTORC1, Wnt/β-catinin, NF-κB, notch and ROS.
存放说明Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
溶解度概述Soluble in ethanol to 0.5 mg/ml
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Fonseca BD et al. Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem287:17530-45 (2012).
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Lu W et al. Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/ß-catenin pathway. PLoS One6:e29290 (2011).
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Jin Y et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res70:2516-27 (2010).
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