Anti-NGF抗体[AS21] (ab16161)

概述

  • 产品名称Anti-NGF抗体[AS21]
    参阅全部 NGF 一抗
  • 描述
    小鼠单克隆抗体[AS21] to NGF
  • 特异性Recognises 2.5S, 7S and bNGF.
  • 经测试应用适用于: Sandwich ELISA, ELISA, Neutralisingmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant full length protein (Human).

  • 表位Amino acids 46-62 of mature human NGF.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab16161 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Sandwich ELISA Use at an assay dependent dilution.
ELISA Use a concentration of 10 µg/ml. Can be paired for ELISA with Mouse monoclonal [AS18] to NGF (Biotin) (ab16160). (For coating in a two site ELISA with biotin conjugated NGF antibody for mouse NGF). Two site ELISA.
Neutralising Use at an assay dependent dilution. This antibody has been used to neutralize > 90% human NGF bioactivity on PC12 cells at a 200 fold molar excess.

靶标

  • 功能Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
  • 疾病相关Neuropathy, hereditary sensory and autonomic, 5
  • 序列相似性Belongs to the NGF-beta family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta nerve growth factor antibody
    • Beta NGF antibody
    • Beta-nerve growth factor antibody
    • Beta-NGF antibody
    • HSAN5 antibody
    • MGC161426 antibody
    • MGC161428 antibody
    • Nerve growth factor (beta polypeptide) antibody
    • Nerve growth factor antibody
    • Nerve growth factor beta antibody
    • Nerve growth factor beta polypeptide antibody
    • Nerve growth factor beta subunit antibody
    • NGF antibody
    • NGF_HUMAN antibody
    • NGFB antibody
    • NID67 antibody
    see all

Anti-NGF antibody [AS21] (ab16161)参考文献

ab16161 has not yet been referenced specifically in any publications.

Product Wall


We obtained better results in ELISA with TBS compared to PBS, so I definitely recommend using TBS if possible. The protocol details are as follows, if you need more details than this please let me know and I will contact the lab for them:

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Thank you for your enquiry and patience. This antibody has been used to neutralize more than 90% human NGF bioactivity on PC12 cells at a 200 fold molar excess. Unfortunately, I cannot obtain additional details regarding this. If you have any additiona...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"