概述

  • 产品名称Anti-NGF抗体
    参阅全部 NGF 一抗
  • 描述
    羊多克隆抗体to NGF
  • 特异性Specificity was demonstrated by ELISA which showed there was less than 1% cross-reactivity against recombinant human Brain Derived Neurotrophic Factor (BDNF) and Neurotrophin 4 (NT4). There was approximately 2% cross reactivity with Neurotrophin 3 (NT3).
  • 经测试应用适用于: WB, ELISA, Inhibition Assay, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Native mouse salivary gland NGF with a purity greater than 95%.

性能

应用

Our Abpromise guarantee covers the use of ab49205 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 27 kDa.
ELISA Use a concentration of 1 - 10 µg/ml.
Inhibition Assay Use at an assay dependent dilution. Use neat for in vivo animal studies at 2-10 ug/g body weight (ED50).
IHC-Fr Use a concentration of 1 - 10 µg/ml.

靶标

  • 功能Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
  • 疾病相关Neuropathy, hereditary sensory and autonomic, 5
  • 序列相似性Belongs to the NGF-beta family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta nerve growth factor antibody
    • Beta NGF antibody
    • Beta-nerve growth factor antibody
    • Beta-NGF antibody
    • HSAN5 antibody
    • MGC161426 antibody
    • MGC161428 antibody
    • Nerve growth factor (beta polypeptide) antibody
    • Nerve growth factor antibody
    • Nerve growth factor beta antibody
    • Nerve growth factor beta polypeptide antibody
    • Nerve growth factor beta subunit antibody
    • NGF antibody
    • NGF_HUMAN antibody
    • NGFB antibody
    • NID67 antibody
    see all

Anti-NGF antibody (ab49205)参考文献

This product has been referenced in:
  • Nakano Y  et al. A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. PLoS Genet 9:e1003364 (2013). IHC-Fr ; Human . Read more (PubMed: 23593010) »
  • Kawakami M  et al. Functional transplantation of salivary gland cells differentiated from mouse early ES cells in vitro. Hum Cell 26:80-90 (2013). Read more (PubMed: 23681939) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"