概述

  • 产品名称
  • 描述
    山羊多克隆抗体to NGF
  • 经测试应用
    适用于: ELISA, WB, Neutralisingmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Recombinant full length rat NGF beta protein expressed in Sf 21 insect cells.

  • 阳性对照
    • Tested with human erythroleukemic cells (TF-1) expressing recombinant rat NGF beta.

性能

应用

Our Abpromise guarantee covers the use of ab10837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use a concentration of 0.5 - 1 µg/ml.
WB Use a concentration of 0.1 - 0.2 µg/ml. Detects a band of approximately 13.2 kDa.
Neutralising Use a concentration of 0.05 - 0.15 µg/ml.

靶标

  • 功能
    Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
  • 疾病相关
    Neuropathy, hereditary sensory and autonomic, 5
  • 序列相似性
    Belongs to the NGF-beta family.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta nerve growth factor antibody
    • Beta NGF antibody
    • Beta-nerve growth factor antibody
    • Beta-NGF antibody
    • HSAN5 antibody
    • MGC161426 antibody
    • MGC161428 antibody
    • Nerve growth factor (beta polypeptide) antibody
    • Nerve growth factor antibody
    • Nerve growth factor beta antibody
    • Nerve growth factor beta polypeptide antibody
    • Nerve growth factor beta subunit antibody
    • NGF antibody
    • NGF_HUMAN antibody
    • NGFB antibody
    • NID67 antibody
    see all

实验方案

文献

This product has been referenced in:
  • Huang M  et al. Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells. Oncotarget 7:74917-74930 (2016). Read more (PubMed: 27732946) »

See 1 Publication for this product

客户评价及客户问答

Thank you for providing some more useful information about your experimental system. I understand now from your recent e-mail, that you used Cos-7 cells (monkey) transfected with a vector carrying the coding part of the human NGFb gene. I have disc...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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