概述

  • 产品名称Anti-NFkB Inducing Kinase NIK抗体
    参阅全部 NFkB Inducing Kinase NIK 一抗
  • 描述
    兔多克隆抗体to NFkB Inducing Kinase NIK
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to amino acids 931-947 of Human NFkB Inducing Kinase NIK.

  • 阳性对照
    • 293 whole cell lysate
  • 常规说明NIK: NFkB Inducing Kinase

性能

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应用

Our Abpromise guarantee covers the use of ab8111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Can be blocked with NFkB Inducing Kinase NIK peptide (ab8385).
ICC/IF Use at an assay dependent concentration. PubMed: 21896778

靶标

  • 功能Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
  • 组织特异性Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.
  • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.
    Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MAP3K14 antibody
    • FTDCR1B antibody
    • HS antibody
    • HsNIK antibody
    • M3K14_HUMAN antibody
    • Map3k14 antibody
    • Mitogen activated protein kinase kinase kinase 14 antibody
    • Mitogen-activated protein kinase kinase kinase 14 antibody
    • NF kappa beta inducing kinase antibody
    • NF-kappa-beta-inducing kinase antibody
    • NIK antibody
    • Serine/threonine-protein kinase NIK antibody
    see all

Anti-NFkB Inducing Kinase NIK antibody (ab8111)参考文献

This product has been referenced in:
  • Ganeff C  et al. Induction of the alternative NF-?B pathway by lymphotoxin aß (LTaß) relies on internalization of LTß receptor. Mol Cell Biol 31:4319-34 (2011). ICC/IF ; Human . Read more (PubMed: 21896778) »

See 1 Publication for this product

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