概述

  • 产品名称NFAT1肽

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab4905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the monoclonal antibody that reacts with this product and NFAT 1, catalog ab2722. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

常规信息

  • 别名
    • AI607462
    • cytoplasmic 2
    • KIAA0611
    • NF ATc2
    • NF ATp
    • NF-ATc2
    • NF-ATp
    • NFAC2_HUMAN
    • NFAT 1
    • NFAT pre existing subunit
    • NFAT pre-existing subunit
    • NFAT transcription complex, preexisting component
    • NFAT1
    • NFAT1-D
    • NFATc2
    • NFATp
    • Nuclear factor of activated T cells cytoplasmic 2
    • Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2
    • Nuclear factor of activated T cells pre-existing component
    • Nuclear factor of activated T cells, preexisting component
    • Nuclear factor of activated T-cells
    • Preexisting nuclear factor of activated T cells 2
    • T cell transcription factor NFAT 1
    • T-cell transcription factor NFAT1
    see all
  • 功能Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF.
  • 组织特异性Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas.
  • 序列相似性Contains 1 RHD (Rel-like) domain.
  • 结构域Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
  • 翻译后修饰In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity.
  • 细胞定位Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
  • Information by UniProt

NFAT1 peptide (ab4905)参考文献

ab4905 has not yet been referenced specifically in any publications.

Product Wall

The molecular weight of this peptide is ~2.4 kDa. Let me know if you have any additional questions.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"