Anti-Neutrophil Elastase抗体[11-207.2] (ab41179)

概述

  • 产品名称Anti-Neutrophil Elastase抗体[11-207.2]
    参阅全部 Neutrophil Elastase 一抗
  • 描述
    小鼠单克隆抗体[11-207.2] to Neutrophil Elastase
  • 经测试应用适用于: ELISA, Inhibition Assaymore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length native protein (purified) (Human) Neutrophil Elastase

性能

应用

Our Abpromise guarantee covers the use of ab41179 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/800.
Inhibition Assay Use at an assay dependent dilution.

靶标

  • 功能Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
  • 组织特异性Bone marrow cells.
  • 疾病相关Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.
    Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:202700]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.
  • 序列相似性Belongs to the peptidase S1 family. Elastase subfamily.
    Contains 1 peptidase S1 domain.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Bone marrow serine protease antibody
    • ELA2 antibody
    • ELANE antibody
    • Elastase 2 antibody
    • Elastase 2 neutrophil antibody
    • Elastase neutrophil expressed antibody
    • Elastase-2 antibody
    • ELNE_HUMAN antibody
    • GE antibody
    • Granulocyte derived elastase antibody
    • HLE antibody
    • HNE antibody
    • Human leukocyte elastase antibody
    • Leukocyte elastase antibody
    • Medullasin antibody
    • NE antibody
    • Neutrophil elastase antibody
    • PMN E antibody
    • PMN elastase antibody
    • Polymorphonuclear elastase antibody
    • SCN1 antibody
    see all

Anti-Neutrophil Elastase antibody [11-207.2] (ab41179)参考文献

This product has been referenced in:
  • Zoega M  et al. Proteinase 3 carries small unusual carbohydrates and associates with alpha-defensins. J Proteomics 75:1472-85 (2012). Read more (PubMed: 22138257) »

See 1 Publication for this product

Product Wall

Thank you for our reply and for kindly providing these details. I am sorry we regrettably do not have anything that exactly fits your requirements on this occasion. All the polyclonal antibodies to neutrophil elastase are not purified, they are...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"