Anti-Neurturin抗体[MM0486-5X51] (ab90450)

概述

  • 产品名称Anti-Neurturin抗体[MM0486-5X51]
    参阅全部 Neurturin 一抗
  • 描述
    小鼠单克隆抗体[MM0486-5X51] to Neurturin
  • 经测试应用适用于: WB, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment corresponding to the extracellular domain of Human Neurturin.

  • 常规说明


    Suitable for the neutralization of ligand/receptor interaction.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • Primary antibody说明Suitable for the neutralization of ligand/receptor interaction.
  • 克隆单克隆
  • 克隆编号MM0486-5X51
  • 同种型IgG2
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab90450 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 22 kDa.
Neutralising Use at an assay dependent dilution.

靶标

  • 功能Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
  • 疾病相关Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
  • 序列相似性Belongs to the TGF-beta family. GDNF subfamily.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Neurturin antibody
    • Neurturin precursor antibody
    • NRTN antibody
    • NRTN_HUMAN antibody
    • NTN antibody
    • prepro-neurturin antibody
    see all

Anti-Neurturin antibody [MM0486-5X51] 图像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4µm) labelling Neurturin with ab90450. Tissue was treated with 15µg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.

Anti-Neurturin antibody [MM0486-5X51] (ab90450)参考文献

ab90450 has not yet been referenced specifically in any publications.

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