概述

  • 产品名称Anti-Neurturin抗体
    参阅全部 Neurturin 一抗
  • 描述
    兔多克隆抗体to Neurturin
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide, corresponding to amino acids 178-193 of Human Neurturin (Peptide available as ab8393.)

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液PBS with 0.02% sodium azide
  • Concentration information loading...
  • 纯度IgG fraction
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab8061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 14 kDa.Can be blocked with Neurturin peptide (ab8393).
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
  • 疾病相关Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
  • 序列相似性Belongs to the TGF-beta family. GDNF subfamily.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Neurturin antibody
    • Neurturin precursor antibody
    • NRTN antibody
    • NRTN_HUMAN antibody
    • NTN antibody
    • prepro-neurturin antibody
    see all

Anti-Neurturin antibody 图像

  • All lanes : Anti-Neurturin antibody (ab8061) at 1/500 dilution

    Lane 1 : 10ng full length recombinant Neurturin in HeLa cell lysate
    Lane 2 : 2.5ng full length recombinant Neurturin in HeLa cell lysate
  • ab8061 at 5µg/ml staining Neurturin in human brain tissue by IHC.

Anti-Neurturin antibody (ab8061)参考文献

This product has been referenced in:
  • Wang K  et al. The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer. Carcinogenesis N/A:N/A (2013). IHC ; Human . Read more (PubMed: 24067900) »
  • Demir IE  et al. Neuronal plasticity in chronic pancreatitis is mediated via the neurturin/GFRa2 axis. Am J Physiol Gastrointest Liver Physiol 303:G1017-28 (2012). IHC ; Human . Read more (PubMed: 22961804) »

See all 2 Publications for this product

Product Wall

Application Western blot
Sample Human Recombinant protein (Extracts of transfected hNRTN COS-1 cells)
Gel Running Conditions Reduced Denaturing
Loading amount 15 µg
Specification Extracts of transfected hNRTN COS-1 cells
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 25°C
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提交于 Aug 07 2015

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"