Anti-Neuroserpin抗体(ab32901)

概述

  • 产品名称Anti-Neuroserpin抗体
    参阅全部 Neuroserpin 一抗
  • 描述
    山羊多克隆抗体to Neuroserpin
  • 经测试应用适用于: ICC/IF, IHC-FoFr, WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Chicken, Chimpanzee
  • 免疫原

    Synthetic peptide:

    TMNTSGHDFEEL

    (Human)(C-terminal)

  • 阳性对照
    • Human brain lysate

性能

应用

Our Abpromise guarantee covers the use of ab32901 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration.
IHC-FoFr Use at an assay dependent concentration.
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 48 kDa.
ELISA 1/32000.

靶标

  • 功能Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
  • 组织特异性Predominantly expressed in the brain.
  • 疾病相关Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.
  • 序列相似性Belongs to the serpin family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp781N13156 antibody
    • Neuroserpin antibody
    • NEUS_HUMAN antibody
    • Peptidase inhibitor 12 antibody
    • PI-12 antibody
    • PI12 antibody
    • Protease inhibitor 12 antibody
    • Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1 antibody
    • Serine or cysteine proteinase inhibitor clade I member 1 antibody
    • Serpin I1 antibody
    • Serpin peptidase inhibitor clade I (neuroserpin) member 1 antibody
    • SERPINI1 antibody
    see all

Anti-Neuroserpin antibody 图像

  • Anti-Neuroserpin antibody (ab32901) at 1 µg/ml + Human Brain lysate (35µg protein in RIPA buffer)

    Predicted band size : 48 kDa

Anti-Neuroserpin antibody (ab32901)参考文献

ab32901 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (PFA perfusion fixed frozen sections)
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 2% · Temperature: 25°C
Sample Mouse Cell (brain hemisphere coronal sections)
Specification brain hemisphere coronal sections
Permeabilization Yes - 0.1% Triton-X
Fixative Paraformaldehyde
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提交于 Jul 05 2013

Thank you for your enquiry. The sequence comparison shows only 33% identity between the ab32901 immunogenic peptide and mouse serpini2. The file for this comparison is found at this link for the next 24 hours: http://www.ebi.ac.uk/cgi-bin/clust...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"