Anti-Neuroserpin抗体[1D10] (ab125097)

概述

  • 产品名称Anti-Neuroserpin抗体[1D10]
    参阅全部 Neuroserpin 一抗
  • 描述
    小鼠单克隆抗体[1D10] to Neuroserpin
  • 经测试应用适用于: Sandwich ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length mature protein, corresponding to amino acids 17-410 of Human Neuroserpin with 26kDa proprietary tag (AAH18043).

  • 阳性对照
    • HeLa cell lysate;, Hman Brain cortex tissue; recombinant protein.

性能

应用

Our Abpromise guarantee covers the use of ab125097 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Sandwich ELISA Use at an assay dependent concentration.
WB 1/500 - 1/1000. Predicted molecular weight: 46 kDa.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
  • 组织特异性Predominantly expressed in the brain.
  • 疾病相关Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.
  • 序列相似性Belongs to the serpin family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DKFZp781N13156 antibody
    • Neuroserpin antibody
    • NEUS_HUMAN antibody
    • Peptidase inhibitor 12 antibody
    • PI-12 antibody
    • PI12 antibody
    • Protease inhibitor 12 antibody
    • Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1 antibody
    • Serine or cysteine proteinase inhibitor clade I member 1 antibody
    • Serpin I1 antibody
    • Serpin peptidase inhibitor clade I (neuroserpin) member 1 antibody
    • SERPINI1 antibody
    see all

Anti-Neuroserpin antibody [1D10] 图像

  • Anti-Neuroserpin antibody [1D10] (ab125097) at 1/500 dilution + HeLa cell lysate

    Predicted band size : 46 kDa
  • ab125097, at 5 µg/ml, staining Neuroserpin in Formalin-fixed, Paraffin-embedded Human brain cortex tissue by Immunohistochemistry
  • Using ab125097 as a capture antibody, the detection limit for recombinant proprietary tagged Neuroserpin is approximately 0.3ng/ml.

Anti-Neuroserpin antibody [1D10] (ab125097)参考文献

ab125097 has not yet been referenced specifically in any publications.

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