Anti-Neurokinin 1 Receptor抗体(ab466)

概述

  • 产品名称Anti-Neurokinin 1 Receptor抗体
    参阅全部 Neurokinin 1 Receptor 一抗
  • 描述
    兔多克隆抗体to Neurokinin 1 Receptor
  • 特异性This antibody is specific for human NK-1.
  • 经测试应用适用于: Flow Cyt, WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Neurokinin 1 Receptor conjugated to Keyhole Limpet Haemocyanin (KLH).
    Sequence:

    N-MDNVLPVDSDLSPNISTC-COOH

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液PBS with 0.05% sodium azide
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab466 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
WB
ICC/IF
  • 应用说明Flow Cyt: 1/3000.
    ICC/IF: 1/5000 from (PubMed:17190739).
    WB: 1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 45 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
    • 序列相似性Belongs to the G-protein coupled receptor 1 family.
    • 细胞定位Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Neurokinin 1 antibody
      • NK 1 receptor antibody
      • NK 1R antibody
      • NK-1 receptor antibody
      • NK-1R antibody
      • NK1 receptor antibody
      • NK1R antibody
      • NK1R_HUMAN antibody
      • NKIR antibody
      • SPR antibody
      • Substance P receptor antibody
      • Substance-P receptor antibody
      • TAC 1R antibody
      • TAC1R antibody
      • Tachykinin 1 receptor (substance P receptor neurokinin 1 receptor) antibody
      • Tachykinin receptor 1 (substance P receptor neurokinin 1 receptor) antibody
      • Tachykinin receptor 1 antibody
      • TACR1 antibody
      see all

    Anti-Neurokinin 1 Receptor antibody (ab466)参考文献

    This product has been referenced in:
    • Amoruso A  et al. A novel activity for substance P: stimulation of peroxisome proliferator-activated receptor-gamma protein expression in human monocytes and macrophages. Br J Pharmacol 154:144-52 (2008). WB ; Human . Read more (PubMed: 18278062) »
    • El-Nour H  et al. Upregulation of the axonal growth and the expression of substance P and its NK1 receptor in human allergic contact dermatitis. Immunopharmacol Immunotoxicol 28:621-31 (2006). Read more (PubMed: 17190739) »

    See all 4 Publications for this product

    Product Wall

    Thank you for your enquiry. There are published reports stating that the substance P receptor/neurokinin-1 receptor (NK-1R) has two forms: a full-length receptor consisting of 407 aa and a truncated receptor consisting of 311 aa. Research has shown ...

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    Thank you for your enquiry. Unfortunately I cannot comment on whether the antibody recognises the intra- or extra-cellular domain as I am not an expert in the field. I can however tell you that the immunogen for this antibody is the at the N-termin...

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    Thank you for re-sending the information, I was able to open the attachments. Below is the FACS protocol which the researcher who tested it for Novus used. They also used lot C, so the vial that your customer received should be alright. I hope this is ...

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    This antibody has been used in rat tissue for western analysis with success(other applications are unknown)

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"