功能May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
组织特异性Restricted to brain (at protein level).
序列相似性Contains 1 EGF-like domain.
发展阶段Expressed in brain of 3 months, 5 and 10-year-old individuals.
翻译后修饰N-glycosylated. O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation. Phosphorylated; in intracellular and extracellular parts.
细胞定位Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. In neurons, localizes to synaptic junctions (By similarity). Also detected in the endoplasmic reticulum and the Golgi (By similarity). Partially enriched in lipid rafts.