Anti-NeuroD1抗体[3H8] (ab117562)


  • 产品名称Anti-NeuroD1抗体[3H8]
    参阅全部 NeuroD1 一抗
  • 描述
    小鼠单克隆抗体[3H8] to NeuroD1
  • 经测试应用适用于: WB, IHC-P, ICC/IF, Sandwich ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Human NeuroD1 protein.

  • 阳性对照
    • WB: transfected 293T cell line IHC-P: Human testis tissue ICC/IF: HeLa cell



Our Abpromise guarantee covers the use of ab117562 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 40 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 10 µg/ml.
Sandwich ELISA Use at an assay dependent concentration. (recombinant protein).


  • 功能Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
  • 疾病相关Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • 序列相似性Contains 1 basic helix-loop-helix (bHLH) domain.
  • 翻译后修饰Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • atonal antibody
    • basic helix loop helix transcription factor antibody
    • BETA 2 antibody
    • Beta cell E box transactivator 2 antibody
    • BETA2 antibody
    • BHF 1 antibody
    • BHF1 antibody
    • bHLHa3 antibody
    • class A basic helix loop helix protein 3 antibody
    • Class A basic helix-loop-helix protein 3 antibody
    • MODY 6 antibody
    • MODY6 antibody
    • NDF1_HUMAN antibody
    • NeuroD antibody
    • NeuroD1 antibody
    • Neurogenic differentiation 1 antibody
    • Neurogenic differentiation factor 1 antibody
    • neurogenic helix loop helix protein NEUROD antibody
    • Neuronal differentiation 1 antibody
    see all

Anti-NeuroD1 antibody [3H8] 图像

  • ab117562, at 5 µg/ml, staining NeuroD1 in formalin fixed, paraffin embedded Human testis tissue by Immunohistochemistry.
  • All lanes : Anti-NeuroD1 antibody [3H8] (ab117562)

    Lane 1 : transfected 293T cell line lysate
    Lane 2 : non-transfected 293T cell line lysate

    Predicted band size : 40 kDa
  • ab117562, at 10 µg/ml, staining NeuroD1 in Hela cell by Immunofluorescence.
  • Detection limit for recombinant proprietary tagged NeuroD1 is approximately 0.03 ng/ml as a capture antibody.

Anti-NeuroD1 antibody [3H8] (ab117562)参考文献

ab117562 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (Testis)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citric acid
Permeabilization No
Specification Testis
Blocking step BSA as blocking agent for 10 minute(s) · Concentration: 1% · Temperature: 21°C
Fixative Formaldehyde

Mr. Carl Hobbs

Verified customer

提交于 Apr 01 2016