Anti-Neurobeachin抗体(ab58563)

概述

  • 产品名称Anti-Neurobeachin抗体
    参阅全部 Neurobeachin 一抗
  • 描述
    山羊多克隆抗体to Neurobeachin
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Cow, Dog, Pufferfish (Fugu), Zebrafish
  • 免疫原

    Synthetic peptide:

    C-DFNRWHYEHQNRY

    , corresponding to C terminal amino acids 2934-2946 of Human Neurobeachin

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab58563 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明This antibody gave a positive result in Peptide ELISA against the immunizing peptide. Antibody detection limit dilution 1/8000.


    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 300 kDa (predicted molecular weight: 327 kDa). Approx 300 kDa band observed in lysates of transfected HEK293 and endogenously in lysates of insulinoma cell line B-TC3.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins.
    • 组织特异性Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine.
    • 序列相似性Belongs to the WD repeat neurobeachin family.
      Contains 1 BEACH domain.
      Contains 5 WD repeats.
    • 结构域RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
    • 细胞定位Cytoplasm. Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • BCL8B antibody
      • FLJ10197 antibody
      • KIAA1544 antibody
      • Lysosomal trafficking regulator 2 antibody
      • Lysosomal-trafficking regulator 2 antibody
      • LYST2 antibody
      • NBEA antibody
      • NBEA_HUMAN antibody
      • Neurobeachin antibody
      • Protein BCL8B antibody
      • Protein neurobeachin antibody
      • RP11-270C18.1 antibody
      see all

    Anti-Neurobeachin antibody 图像

    • All lanes : Anti-Neurobeachin antibody (ab58563) at 1 µg/ml

      Lane 1 : Lysate prepared from non transfected HEK293 T cells
      Lane 2 : Lysate prepared from HEK293 T cells transfected with mouse Neurobeachin

      Developed using the ECL technique

      Predicted band size : 327 kDa
      Observed band size : 300 kDa (why is the actual band size different from the predicted?)

    Anti-Neurobeachin antibody (ab58563)参考文献

    ab58563 has not yet been referenced specifically in any publications.

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