Anti-Neurexin 1抗体(ab79587)

概述

  • 产品名称Anti-Neurexin 1抗体
    参阅全部 Neurexin 1 一抗
  • 描述
    山羊多克隆抗体to Neurexin 1
  • 特异性This antibody is expected to recognise both reported isoforms (NP_004792.1 and NP_620072.1).
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Dog
  • 免疫原

    A synthetic peptide correspoding to a C terminal end of Neurexin 1 (Human)(NP_004792.1 , NP_620072.1)

  • 阳性对照
    • Human brain (Cerebellum) lysates

性能

应用

Our Abpromise guarantee covers the use of ab79587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: Use at an assay dependent dilution. Antibody detection limit in peptide ELISA assay: 1/32000.
    WB: Use at a concentration of 0.05 - 0.1 µg/ml. Predicted molecular weight: 162 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.
    • 组织特异性Brain.
    • 序列相似性Belongs to the neurexin family.
      Contains 3 EGF-like domains.
      Contains 6 laminin G-like domains.
    • 翻译后修饰N-glycosylated.
      O-glycosylated.
    • 细胞定位Cell membrane. Cell junction, synapse. Localized on the pre-synaptic membrane.
    • Information by UniProt
    • 数据库链接
    • 形式The neurexin genes use alternate promoters, splice sites and exons to encode potentially hundreds or thousands of mRNA transcripts.
    • 别名
      • DKFZp313P2036 antibody
      • FLJ35941 antibody
      • Hs.22998 antibody
      • KIAA0578 antibody
      • Neurexin 1 alpha antibody
      • Neurexin 1 beta antibody
      • Neurexin I-alpha antibody
      • Neurexin-1 antibody
      • Neurexin-1-alpha antibody
      • NRX1A_HUMAN antibody
      • NRXN1 antibody
      • PTHSL2 antibody
      • SCZD17 antibody
      see all

    Anti-Neurexin 1 antibody 图像

    Anti-Neurexin 1 antibody (ab79587)参考文献

    ab79587 has not yet been referenced specifically in any publications.

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