概述

  • 产品名称Anti-Netrin 1抗体
    参阅全部 Netrin 1 一抗
  • 描述
    兔多克隆抗体to Netrin 1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Chicken, Human, Xenopus laevis, Zebrafish
  • 免疫原

    Synthetic peptide:

    VQIHILKADKAG

    , corresponding to amino acids 497 - 508 of Mouse Netrin 1

  • 阳性对照
    • Mouse brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab26162 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Detects a band of approximately 67 kDa.

靶标

  • 功能Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
  • 组织特异性Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas.
  • 序列相似性Contains 3 laminin EGF-like domains.
    Contains 1 laminin N-terminal domain.
    Contains 1 NTR domain.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • epididymis tissue protein Li 131P antibody
    • NET1_HUMAN antibody
    • Netrin 1, mouse, homolog of antibody
    • Netrin 1-like antibody
    • Netrin-1 antibody
    • Netrin1 antibody
    • Ntn 1 antibody
    • NTN 1L antibody
    • NTN1 antibody
    • NTN1L antibody
    • Unc6 antibody
    see all

Anti-Netrin 1 antibody 图像

  • All lanes : Anti-Netrin 1 antibody (ab26162) at 1 µg/ml

    Lane 1 : Mouse brain extract (Embryonic day 14)
    Lane 2 : Mouse brain extract (Embryonic day 16)
    Lane 3 : Mouse brain extract (Post natal day 1)
    Lane 4 : Mouse brain extract (Adult)


    Observed band size : 67 kDa (why is the actual band size different from the predicted?)

Anti-Netrin 1 antibody (ab26162)参考文献

This product has been referenced in:
  • van Gils JM  et al. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol 13:136-43 (2012). Read more (PubMed: 22231519) »
  • Foran E  et al. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2. Glia 59:1719-31 (2011). Mouse . Read more (PubMed: 21769946) »

See all 3 Publications for this product

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