Anti-Nesprin3抗体[Nsp3] (ab123031)
Key features and details
- Mouse monoclonal [Nsp3] to Nesprin3
- Suitable for: ICC/IF
- Reacts with: Mouse
- Isotype: IgG1
概述
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产品名称
Anti-Nesprin3抗体[Nsp3]
参阅全部 Nesprin3 一抗 -
描述
小鼠单克隆抗体[Nsp3] to Nesprin3 -
宿主
Mouse -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: Mouse
不与反应: Human, Zebrafish -
免疫原
Recombinant fragment corresponding to Mouse Nesprin3. Fusion protein encoding the seventh spectrin repeat of Nesprin3 and a proprietary protein.
Database link: Q4FZC9 -
阳性对照
- Mouse embryonic fibroblasts.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
Nsp3 -
骨髓瘤
Sp2/0 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab123031于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ICC/IF | (1) |
Use at an assay dependent concentration.
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说明 |
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ICC/IF
Use at an assay dependent concentration. |
靶标
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功能
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. -
序列相似性
Belongs to the nesprin family.
Contains 1 KASH domain.
Contains 2 spectrin repeats. -
结构域
The KASH domain is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains. -
细胞定位
Nucleus outer membrane. Located at the rough reticulum endoplasmic (RER) in some cells. - Information by UniProt
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数据库链接
- Entrez Gene: 212073 Mouse
- SwissProt: Q4FZC9 Mouse
- Unigene: 212688 Mouse
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别名
- C14orf49 antibody
- Chromosome 14 open reading frame 49 antibody
- FLJ25605 antibody
see all
图片
数据表及文件
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Datasheet download
文献 (3)
ab123031 被引用在 3 文献中.
- Pieuchot L et al. Curvotaxis directs cell migration through cell-scale curvature landscapes. Nat Commun 9:3995 (2018). PubMed: 30266986
- Alam SG et al. The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity. Sci Rep 6:38063 (2016). ICC/IF . PubMed: 27905489
- Gutiérrez-Fernández A et al. Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid. EMBO J 34:1875-88 (2015). PubMed: 25991604