功能Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.
序列相似性Belongs to the nesprin family. Contains 1 KASH domain. Contains 2 spectrin repeats.
结构域The KASH domain is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains.
细胞定位Nucleus outer membrane. Located at the rough reticulum endoplasmic (RER) in some cells.