Anti-Nephronophthisis抗体(ab90829)

概述

  • 产品名称Anti-Nephronophthisis抗体
    参阅全部 Nephronophthisis 一抗
  • 描述
    兔多克隆抗体to Nephronophthisis
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal amino acids 467-516 (

    ILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIPAKTYELFLNGGT

    ) of Human Nephronophthisis (NP_000263).

  • 阳性对照
    • Human fetal heart lysate

性能

应用

Our Abpromise guarantee covers the use of ab90829 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 83 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 相关性Juvenile nephronophthsis, an autosomal recessive cystic kidney disease, is the primary cause for chronic renal failure in children. The gene for nephronophthsis type 1 (NPHP1) has recently been identified. Nephronophthisis together with Cas it may play a role in the control of epithelial cell polarity. Seems to help to recruit protein tyrosine kinase 2 beta (PTK2B) to cell matrix adhesions, thereby initiating phosphorylation of PTK2B and PTK2B-dependent signaling . NPHP1 expression has been studied in mouse and human systems. Expression in the human adult is widespread but relatively weak. In contrast, expression in adult mouse is strong and localized to the testis. In situ hybridization to whole mouse embryo demonstrates widespread and consistently strong expression throughout all developmental stages. 4 isoforms exist, produced by alternative splicing.
  • 细胞定位Cell junction, adherens junction. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell junction, tight junction.
  • 数据库链接
  • 别名
    • JBTS4 antibody
    • Juvenile nephronophthisis 1 protein antibody
    • Nephrocystin 1 antibody
    • nephronophthisis 1 (juvenile) antibody
    • Nephronophthisis antibody
    • NPH1 antibody
    • NPHP1 antibody
    • SLSN1 antibody
    see all

Anti-Nephronophthisis antibody 图像

  • Anti-Nephronophthisis antibody (ab90829) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 83 kDa

Anti-Nephronophthisis antibody (ab90829)参考文献

ab90829 has not yet been referenced specifically in any publications.

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