概述

  • 产品名称Anti-Nephronophthisis抗体
    参阅全部 Nephronophthisis 一抗
  • 描述
    兔多克隆抗体to Nephronophthisis
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Fusion protein of a portion of mouse NPH corresponding to amino acid residues 612-691 (pic region).

性能

应用

Our Abpromise guarantee covers the use of ab11501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 - 10 µg/ml. Detects a band of approximately 90 kDa.
IP Use a concentration of 2 - 10 µg/ml.

靶标

  • 相关性Juvenile nephronophthsis, an autosomal recessive cystic kidney disease, is the primary cause for chronic renal failure in children. The gene for nephronophthsis type 1 (NPHP1) has recently been identified. Nephronophthisis together with Cas it may play a role in the control of epithelial cell polarity. Seems to help to recruit protein tyrosine kinase 2 beta (PTK2B) to cell matrix adhesions, thereby initiating phosphorylation of PTK2B and PTK2B-dependent signaling . NPHP1 expression has been studied in mouse and human systems. Expression in the human adult is widespread but relatively weak. In contrast, expression in adult mouse is strong and localized to the testis. In situ hybridization to whole mouse embryo demonstrates widespread and consistently strong expression throughout all developmental stages. 4 isoforms exist, produced by alternative splicing.
  • 细胞定位Cell junction, adherens junction. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell junction, tight junction.
  • 数据库链接
  • 别名
    • JBTS4 antibody
    • Juvenile nephronophthisis 1 protein antibody
    • Nephrocystin 1 antibody
    • nephronophthisis 1 (juvenile) antibody
    • Nephronophthisis antibody
    • NPH1 antibody
    • NPHP1 antibody
    • SLSN1 antibody
    see all

Anti-Nephronophthisis antibody (ab11501)参考文献

This product has been referenced in:
  • Murga-Zamalloa CA  et al. Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in mammalian retinas. Mol Vis 16:1373-81 (2010). IP ; Mouse . Read more (PubMed: 20664800) »

See 1 Publication for this product

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