Anti-Nephrocystin 4抗体(ab111408)

概述

  • 产品名称Anti-Nephrocystin 4抗体
    参阅全部 Nephrocystin 4 一抗
  • 描述
    兔多克隆抗体to Nephrocystin 4
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from an internal sequence from the Human Nephrocystin 4 protein (O75161).

  • 阳性对照
    • human colon carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab111408 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 组织特异性Expressed in kidney, skeletal muscle, heart and liver, and to a lesser extent in brain and lung.
  • 疾病相关Defects in NPHP4 are the cause of nephronophthisis type 4 (NPHP4) [MIM:606966]; also known as familial juvenile nephronophthisis 4. NPHP4 is an autosomal recessive inherited disease resulting in end-stage renal disease at age ranging between 6 and 35 years. It is a progressive tubulo-interstitial kidney disorder characterized by polydipsia, polyuria, anemia and growth retardation. The most prominent histological features are modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.
    Defects in NPHP4 are the cause of Senior-Loken syndrome type 4 (SLSN4) [MIM:606996]. SLSN is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney, with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life.
  • 序列相似性Belongs to the NPHP4 family.
  • 细胞定位Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • KIAA0673 antibody
    • Nephrocystin-4 antibody
    • nephronophthisis 4 antibody
    • Nephroretinin antibody
    • NPHP4 antibody
    • NPHP4_HUMAN antibody
    • POC10 antibody
    • POC10 centriolar protein homolog antibody
    • SLSN4 antibody
    see all

Anti-Nephrocystin 4 antibody 图像

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using anti Nephrocystin 4 antibody (ab111408). The picture on the right is treated with the synthesized peptide.

Anti-Nephrocystin 4 antibody (ab111408)参考文献

ab111408 has not yet been referenced specifically in any publications.

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