Anti-Nephrin抗体,prediluted (ab82113)

概述

  • 产品名称
    Anti-Nephrin抗体,prediluted
    参阅全部 Nephrin 一抗
  • 描述
    兔多克隆抗体to Nephrin,prediluted
  • 宿主
    Rabbit
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human Nephrin (internal sequence).

  • 阳性对照
    • Human kidney

性能

应用

Our Abpromise guarantee covers the use of ab82113 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

靶标

  • 功能
    Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
  • 组织特异性
    Specifically expressed in podocytes of kidney glomeruli.
  • 疾病相关
    Defects in NPHS1 are the cause of nephrotic syndrome type 1 (NPHS1) [MIM:256300]; also known as Finnish congenital nephrosis (CNF). A renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.
  • 序列相似性
    Belongs to the immunoglobulin superfamily.
    Contains 1 fibronectin type-III domain.
    Contains 8 Ig-like C2-type (immunoglobulin-like) domains.
  • 发展阶段
    In 23-week-old embryo found in epithelial podocytes of the periphery of mature and developing glomeruli.
  • 翻译后修饰
    Phosphorylated on tyrosine residues.
  • 细胞定位
    Cell membrane. Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CNF antibody
    • Nephrin antibody
    • Nephrosis 1 congenital Finnish type antibody
    • Nephrosis 1, congenital, Finnish type (nephrin) antibody
    • NPHN antibody
    • NPHN_HUMAN antibody
    • NPHS 1 antibody
    • Nphs1 antibody
    • Renal glomerulus specific cell adhesion receptor antibody
    • Renal glomerulus-specific cell adhesion receptor antibody
    see all

图片

  • ab82113, prediluted, staining Nephrin in formalin fixed, paraffin embedded human kidney by Immunohistochemistry.

文献

ab82113 has not yet been referenced specifically in any publications.

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