概述

  • 产品名称Anti-Nephrin抗体
    参阅全部 Nephrin 一抗
  • 描述
    兔多克隆抗体to Nephrin
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to an internal region of Human Nephrin.

  • 阳性对照
    • Human kidney tissue

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab92887 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol by boiling tissue section in 10mM Citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
    • 组织特异性Specifically expressed in podocytes of kidney glomeruli.
    • 疾病相关Defects in NPHS1 are the cause of nephrotic syndrome type 1 (NPHS1) [MIM:256300]; also known as Finnish congenital nephrosis (CNF). A renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.
    • 序列相似性Belongs to the immunoglobulin superfamily.
      Contains 1 fibronectin type-III domain.
      Contains 8 Ig-like C2-type (immunoglobulin-like) domains.
    • 发展阶段In 23-week-old embryo found in epithelial podocytes of the periphery of mature and developing glomeruli.
    • 翻译后修饰Phosphorylated on tyrosine residues.
    • 细胞定位Cell membrane. Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CNF antibody
      • Nephrin antibody
      • Nephrosis 1 congenital Finnish type antibody
      • Nephrosis 1, congenital, Finnish type (nephrin) antibody
      • NPHN antibody
      • NPHN_HUMAN antibody
      • NPHS 1 antibody
      • Nphs1 antibody
      • Renal glomerulus specific cell adhesion receptor antibody
      • Renal glomerulus-specific cell adhesion receptor antibody
      see all

    Anti-Nephrin antibody 图像

    • ab92887, at 1/50 dilution staining Nephrin in formalin-fixed, paraffin-embedded Human kidney tissue.

    Anti-Nephrin antibody (ab92887)参考文献

    ab92887 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab92887.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"