概述

  • 产品名称
  • 描述
    兔多克隆抗体to NEIL2
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a sequence between N terminal amino acids 66-96 of Human NEIL2 (NP_001129220.1, NP_001129218.1, NP_659480.1).

  • 阳性对照
    • HepG2 cell line lysates

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab124106 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab124106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 37 kDa.

靶标

  • 功能
    Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  • 组织特异性
    Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
  • 序列相似性
    Belongs to the FPG family.
    Contains 1 FPG-type zinc finger.
  • 结构域
    The zinc-finger domain is important for DNA binding.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DNA glycosylase/AP lyase Neil2 antibody
    • DNA-(apurinic or apyrimidinic site) lyase Neil2 antibody
    • Endonuclease 8-like 2 antibody
    • Endonuclease VIII-like 2 antibody
    • NEH2 antibody
    • Nei endonuclease VIII like 2 (E. coli) antibody
    • Nei endonuclease VIII like 2 antibody
    • Nei homolog 2 antibody
    • Nei-like 2 antibody
    • Nei-like protein 2 antibody
    • NEI2 antibody
    • NEIL2 antibody
    • NEIL2_HUMAN antibody
    see all

图片

  • Anti-NEIL2 antibody (ab124106) at 1/100 dilution + HepG2 cell line lysates at 35 µg

    Predicted band size : 37 kDa

实验方案

文献

ab124106 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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