概述

  • 产品名称Anti-NEI3抗体
    参阅全部 NEI3 一抗
  • 描述
    兔多克隆抗体to NEI3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from the internal region of Human NEI3.

  • 阳性对照
    • COLO, HuvEc, HepG2 and HeLa cell extracts

性能

应用

Our Abpromise guarantee covers the use of ab110049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 68 kDa.

靶标

  • 功能Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single-stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected.
  • 组织特异性Detected in thymus and testis. Expressed at higher levels in tumor tissue than in the corresponding normal tissues except for pancreas and testis where expression is higher in normal than tumor tissue.
  • 序列相似性Belongs to the FPG family.
    Contains 1 FPG-type zinc finger.
    Contains 1 RanBP2-type zinc finger.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 123 antibody
    • AI449477 antibody
    • BC034753 antibody
    • C85903 antibody
    • DNA glycosylase FPG2 antibody
    • DNA glycosylase hFPG2 antibody
    • DNA glycosylase/AP lyase Neil3 antibody
    • EC 3.2.2.- antibody
    • EC 4.2.99.18 antibody
    • Endonuclease 8-like 3 antibody
    • Endonuclease VIII-like 3 antibody
    • FGP2 antibody
    • FLJ10858 antibody
    • FPG2 antibody
    • hFPG2 antibody
    • hNEI3 antibody
    • MGC27861 antibody
    • MGC36916 antibody
    • Nei endonuclease VIII-like 3 (E. coli) antibody
    • nei endonuclease VIII-like 3 antibody
    • Nei like 3 (E. coli) antibody
    • Nei-like protein 3 antibody
    • NEIL3 antibody
    • NEIL3_HUMAN antibody
    • OTTHUMP00000218810 antibody
    • RGD1310562 antibody
    see all

Anti-NEI3 antibody 图像

  • All lanes : Anti-NEI3 antibody (ab110049) at 1/500 dilution

    Lane 1 : COLO cell extract
    Lane 2 : HuvEc cell extract
    Lane 3 : HepG2 cell extract
    Lane 4 : HeLa cell extract
    Lane 5 : HuvEc cell extract with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 68 kDa

Anti-NEI3 antibody (ab110049)参考文献

ab110049 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab110049.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"