Anti-NEI3抗体[2627C1b] (ab58643)

概述

  • 产品名称Anti-NEI3抗体[2627C1b]
    参阅全部 NEI3 一抗
  • 描述
    小鼠单克隆抗体[2627C1b] to NEI3
  • 经测试应用适用于: WB, Dot blotmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment (Human)

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.05% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Purified using protein G column chromatography from culture supernatant of hybridoma culture in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum
  • 克隆单克隆
  • 克隆编号2627C1b
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab58643 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
Dot blot
  • 应用说明Dot: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 68 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single-stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected.
    • 组织特异性Detected in thymus and testis. Expressed at higher levels in tumor tissue than in the corresponding normal tissues except for pancreas and testis where expression is higher in normal than tumor tissue.
    • 序列相似性Belongs to the FPG family.
      Contains 1 FPG-type zinc finger.
      Contains 1 RanBP2-type zinc finger.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 123 antibody
      • AI449477 antibody
      • BC034753 antibody
      • C85903 antibody
      • DNA glycosylase FPG2 antibody
      • DNA glycosylase hFPG2 antibody
      • DNA glycosylase/AP lyase Neil3 antibody
      • EC 3.2.2.- antibody
      • EC 4.2.99.18 antibody
      • Endonuclease 8-like 3 antibody
      • Endonuclease VIII-like 3 antibody
      • FGP2 antibody
      • FLJ10858 antibody
      • FPG2 antibody
      • hFPG2 antibody
      • hNEI3 antibody
      • MGC27861 antibody
      • MGC36916 antibody
      • Nei endonuclease VIII-like 3 (E. coli) antibody
      • nei endonuclease VIII-like 3 antibody
      • Nei like 3 (E. coli) antibody
      • Nei-like protein 3 antibody
      • NEIL3 antibody
      • NEIL3_HUMAN antibody
      • OTTHUMP00000218810 antibody
      • RGD1310562 antibody
      see all

    Anti-NEI3 antibody [2627C1b] 图像

    Anti-NEI3 antibody [2627C1b] (ab58643)参考文献

    ab58643 has not yet been referenced specifically in any publications.

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    Thank you for your call today and for letting us know about the trouble with these antibodies.

    As we discussed, I'm sending replacement antibodies for each of these targets. A vial of ab9134 should arrive tomorrow on the order ***, and a vial...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"