概述

  • 产品名称Anti-Necdin抗体
    参阅全部 Necdin 一抗
  • 描述
    小鼠单克隆抗体to Necdin
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: WKKHSTFGDV RKLITEEFVQ MNYLKYQRVP YVEPPEYEFF WGSRASREIT KMQIMEFLAR VFKKDPQAWP SRYREALEEA RALREANPTA HYPRSSVSED , corresponding to amino acids 222-322 of Human Necdin

性能

应用

Our Abpromise guarantee covers the use of ab55501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 1 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences.
    • 组织特异性Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post-mitotic neurons.
    • 序列相似性Contains 1 MAGE domain.
    • 细胞定位Perikaryon. Nucleus. Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • HsT16328 antibody
      • NDN antibody
      • NECD_HUMAN antibody
      • Necdin antibody
      • Necdin homolog antibody
      • necdin related protein antibody
      • PWCR antibody
      see all

    Anti-Necdin antibody 图像

    • Necdin antibody (ab55501) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human colon.


    • Predicted band size : 36 kDa
      Necdin antibody (ab55501) at 1ug/lane + HL-60 cell lysate at 25ug/lane.

    Anti-Necdin antibody (ab55501)参考文献

    ab55501 has not yet been referenced specifically in any publications.

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