功能Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.
疾病相关Defects in NDUFS8 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
序列相似性Belongs to the complex I 23 kDa subunit family. Contains 2 4Fe-4S ferredoxin-type domains.
Ubiquinoneiron sulfur protein 8, mitochondrial precursor antibody
Anti-NDUFS8 antibody 图像
Western blot - NDUFS8 antibody (ab96123)
Anti-NDUFS8 antibody (ab96123) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size : 24 kDa
Anti-NDUFS8 antibody (ab96123)参考文献
This product has been referenced in:
Machado AK et al. Neuroprotective Effects of Açaí (Euterpe oleracea Mart.) against Rotenone In Vitro Exposure. Oxid Med Cell Longev2016:8940850 (2016).
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