Anti-Ndfip1抗体[N1Nterm15-32.8] (ab62283)

概述

性能

应用

Our Abpromise guarantee covers the use of ab62283 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 25 kDa.

靶标

  • 功能Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.
  • 组织特异性Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.
  • 结构域The PY (WW-binding) motifs are required for E3 ubiquitin-protein ligase binding and activation and for ubiquitination.
  • 翻译后修饰Ubiquitinated by NEDD4 and ITCH; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation.
    Undergoes transient tyrosine phosphorylation following EGF stimulation, most probably by catalyzed by SRC. Phosphorylation SRC is enhanced in the presence of NDFIP2 which may act as a scaffold to recruit SRC to NDFIP1.
  • 细胞定位Endosome membrane. Golgi apparatus membrane. Secreted. Detected in exosomes and secreted via the exosomal pathway.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 0610010M22Rik antibody
    • Breast cancer associated protein SGA 1M antibody
    • Breast cancer-associated protein SGA-1M antibody
    • MGC10924 antibody
    • N4WBP5 antibody
    • Ndfip1 antibody
    • Nedd4 family interacting protein 1 antibody
    • NEDD4 family-interacting protein 1 antibody
    • NEDD4 WW domain binding protein 5 antibody
    • NEDD4 WW domain-binding protein 5 antibody
    • NFIP1_HUMAN antibody
    • Putative MAPK activating protein PM13 antibody
    • Putative MAPK-activating protein PM13 antibody
    • Putative NF kappa B activating protein 164 antibody
    • Putative NF-kappa-B-activating protein 164 antibody
    • Putative NFKB and MAPK activating protein antibody
    • Putative NFKB and MAPK-activating protein antibody
    see all

Anti-Ndfip1 antibody [N1Nterm15-32.8] (ab62283)参考文献

ab62283 has not yet been referenced specifically in any publications.

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