概述

  • 产品名称Anti-NCS1抗体
    参阅全部 NCS1 一抗
  • 描述
    兔多克隆抗体to NCS1
  • 经测试应用适用于: WB, ELISA, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant full length protein Mouse NCS1 protein with extensive post-translational modifications.

  • 阳性对照
    • Human brain, cerebellum tissue
  • 常规说明Dilute only prior to immediate use.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 0.88% Sodium chloride, 0.27% Potassium phosphate
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab116230 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 22 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.
  • 序列相似性Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • 细胞定位Golgi apparatus > Golgi stack membrane. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cytoplasm > perinuclear region. Cell membrane. Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 9430075O15Rik antibody
    • A730032G13Rik antibody
    • AI836659 antibody
    • DKFZp761L1223 antibody
    • FLUP antibody
    • FREQ antibody
    • Frequenin antibody
    • Frequenin homolog (Drosophila) antibody
    • Frequenin homolog antibody
    • Frequenin like protein antibody
    • Frequenin, Drosophila, homolog of antibody
    • Frequenin-like protein antibody
    • Frequenin-like ubiquitous protein antibody
    • Mfreq antibody
    • NCS 1 antibody
    • NCS-1 antibody
    • ncs1 antibody
    • NCS1_HUMAN antibody
    • Neuronal calcium sensor 1 antibody
    • Neuronal Calicum Sensor 1 antibody
    see all

Anti-NCS1 antibody 图像

  • ab116230, at 5 µg/ml, staining NCS1 in formalin fixed, paraffin embedded Human brain (cerebellum) tissue by Immunohistochemistry. After incubation with the primary antibody, slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Anti-NCS1 antibody (ab116230)参考文献

ab116230 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab116230.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"