Anti-NCR3抗体[y4E6] (ab26250)

概述

  • 产品名称Anti-NCR3抗体[y4E6]
    参阅全部 NCR3 一抗
  • 描述
    小鼠单克隆抗体[y4E6] to NCR3
  • 特异性This antibody is specific for NCR3 and does not cross react with NKp46 and NKp44
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: extracellular domain(19-138aa) of human NCR3 purified from E. coli.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号y4E6
  • 骨髓瘤P3x63-Ag8.653
  • 同种型IgG1
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab26250 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB 1/500 - 1/2000. Predicted molecular weight: 22 kDa.

靶标

  • 功能Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
  • 组织特异性Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
  • 序列相似性Belongs to the natural cytotoxicity receptor (NCR) family.
    Contains 1 Ig-like (immunoglobulin-like) domain.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1C7 antibody
    • Activating natural killer receptor p30 antibody
    • Activating NK A1 receptor antibody
    • CD337 antibody
    • CD337 antigen antibody
    • LY117 antibody
    • Lymphocyte antigen 117 antibody
    • MALS antibody
    • Natural cytotoxicity triggering receptor 3 antibody
    • Natural killer cell p30 related protein antibody
    • Natural killer cell p30-related protein antibody
    • Ncr3 antibody
    • NCTR3_HUMAN antibody
    • NK-p30 antibody
    • NKp30 antibody
    see all

Anti-NCR3 antibody [y4E6] 图像

  • Anti-NCR3 antibody [y4E6] (ab26250) at 1/1000 dilution + human recombinant protein NCR3 (residues 19-138) (50ng)

    Secondary
    goat anti-mouse secondary antibody conjugated to HRP

    Predicted band size : 22 kDa

Anti-NCR3 antibody [y4E6] (ab26250)参考文献

ab26250 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (spleen)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: citrate buffer
Permeabilization No
Specification spleen
Blocking step ab80436 protein block as blocking agent for 15 minute(s) · Concentration: 100% · Temperature: RT°C
Fixative Formaldehyde
Username

Abcam user community

Verified customer

提交于 Jul 22 2016

Thank you for your enquiry. To answer your questions: 1. Unfortunately we do not sell the NKp30 receptor in solution. 2) A recombinant fragment of the extracellular domain(19-138aa) of human NCR3 was used as the immunogen for anti-NKp30 (ab26...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"