概述

描述

  • 性质Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab4909 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the monoclonal antibody that reacts with this product and SMRT, catalog ab2780. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

常规信息

  • 别名
    • CTG 26
    • CTG repeat protein 26
    • CTG26
    • N CoR2
    • N-CoR2
    • NCoR 2
    • Ncor2
    • NCOR2_HUMAN
    • Nuclear Receptor Co-Repressor 2
    • Nuclear receptor corepressor 2
    • retinoic-acid-receptor-associated corepressor
    • Silencing Mediator for Retanoid and Thyroid Hormone Receptors
    • Silencing mediator of retinoic acid and thyroid hormone receptor
    • SMAP 270
    • SMAP270
    • SMRT
    • SMRTE
    • SMRTE tau
    • T3 receptor associating factor
    • T3 receptor-associating factor
    • Thyroid retinoic acid receptor associated corepressor
    • Thyroid-
    • TNRC 14
    • TNRC14
    • TRAC
    • TRAC 1
    • TRAC1
    see all
  • 功能Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
  • 组织特异性Ubiquitous. High levels of expression are detected in lung, spleen and brain.
  • 序列相似性Belongs to the N-CoR nuclear receptor corepressors family.
    Contains 2 SANT domains.
  • 结构域The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
    The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
  • 细胞定位Nucleus.
  • Information by UniProt

NCOR2 peptide (ab4909)参考文献

ab4909 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"